Parkinsonian deficits in context-dependent regulation of standing postural control
Identifieur interne : 002657 ( Main/Exploration ); précédent : 002656; suivant : 002658Parkinsonian deficits in context-dependent regulation of standing postural control
Auteurs : Lesley A. Brown [Canada] ; Jon B. Doan [Canada] ; Ian Q. Whishaw [Canada] ; Oksana Suchowersky [Canada]Source :
- Neuroscience letters [ 0304-3940 ] ; 2007.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
This study explored whether patients with Parkinson's disease alter the regulation of upright standing according to constraints imposed by the environmental context. The provision of context-dependent adaptations was inferred from the presence of adjustments to standing postural control that would serve to reduce fall risk when balance was challenged by a threatening environmental context. Participants were asked to stand as still as possible in two environmental context conditions that differed in the level of imposed postural threat: LOW threat and HIGH threat. Eight levodopa dependent patients with Parkinson's disease (PD) and eight age-matched control subjects (CTRL) provided the subject sample. PD patients were tested following a 12-h withdrawal of anti-Parkinsonian medications and approximately 1 h post-medication. The CTRL group showed altered postural control in the HIGH threat condition, in a manner that was indicative of appropriate context-dependent regulation of standing. PD patients, in the non-medicated or medicated states, did not modify stance regulation when the environmental context heightened postural threat. Our results extend the current understanding of Parkinsonian deficits in the context-dependent regulation of postural control to include upright standing.
Affiliations:
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Brown</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Balance Research Laboratory, Department of Kinesiology, University of Lethbridge</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Balance Research Laboratory, Department of Kinesiology, University of Lethbridge</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Canadian Centre for Behavioural Neuroscience, University of Lethbridge</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Canadian Centre for Behavioural Neuroscience, University of Lethbridge</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Hotchkiss Brain Institute, University of Calgary</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Doan, Jon B" sort="Doan, Jon B" uniqKey="Doan J" first="Jon B." last="Doan">Jon B. Doan</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Balance Research Laboratory, Department of Kinesiology, University of Lethbridge</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Balance Research Laboratory, Department of Kinesiology, University of Lethbridge</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Canadian Centre for Behavioural Neuroscience, University of Lethbridge</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Canadian Centre for Behavioural Neuroscience, University of Lethbridge</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Hotchkiss Brain Institute, University of Calgary</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Whishaw, Ian Q" sort="Whishaw, Ian Q" uniqKey="Whishaw I" first="Ian Q." last="Whishaw">Ian Q. Whishaw</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Canadian Centre for Behavioural Neuroscience, University of Lethbridge</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Canadian Centre for Behavioural Neuroscience, University of Lethbridge</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Hotchkiss Brain Institute, University of Calgary</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Suchowersky, Oksana" sort="Suchowersky, Oksana" uniqKey="Suchowersky O" first="Oksana" last="Suchowersky">Oksana Suchowersky</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Hotchkiss Brain Institute, University of Calgary</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Clinical Neurosciences, University of Calgary</s1><s3>CAN</s3><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author></analytic><series><title level="j" type="main">Neuroscience letters</title><title level="j" type="abbreviated">Neurosci. lett.</title><idno type="ISSN">0304-3940</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neuroscience letters</title><title level="j" type="abbreviated">Neurosci. lett.</title><idno type="ISSN">0304-3940</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson disease</term><term>Posture</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Posture</term><term>Parkinson maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study explored whether patients with Parkinson's disease alter the regulation of upright standing according to constraints imposed by the environmental context. The provision of context-dependent adaptations was inferred from the presence of adjustments to standing postural control that would serve to reduce fall risk when balance was challenged by a threatening environmental context. Participants were asked to stand as still as possible in two environmental context conditions that differed in the level of imposed postural threat: LOW threat and HIGH threat. Eight levodopa dependent patients with Parkinson's disease (PD) and eight age-matched control subjects (CTRL) provided the subject sample. PD patients were tested following a 12-h withdrawal of anti-Parkinsonian medications and approximately 1 h post-medication. The CTRL group showed altered postural control in the HIGH threat condition, in a manner that was indicative of appropriate context-dependent regulation of standing. PD patients, in the non-medicated or medicated states, did not modify stance regulation when the environmental context heightened postural threat. Our results extend the current understanding of Parkinsonian deficits in the context-dependent regulation of postural control to include upright standing.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Alberta</li></region><settlement><li>Calgary</li></settlement><orgName><li>Université de Calgary</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Brown, Lesley A" sort="Brown, Lesley A" uniqKey="Brown L" first="Lesley A." last="Brown">Lesley A. Brown</name></noRegion><name sortKey="Brown, Lesley A" sort="Brown, Lesley A" uniqKey="Brown L" first="Lesley A." last="Brown">Lesley A. Brown</name><name sortKey="Brown, Lesley A" sort="Brown, Lesley A" uniqKey="Brown L" first="Lesley A." last="Brown">Lesley A. Brown</name><name sortKey="Doan, Jon B" sort="Doan, Jon B" uniqKey="Doan J" first="Jon B." last="Doan">Jon B. Doan</name><name sortKey="Doan, Jon B" sort="Doan, Jon B" uniqKey="Doan J" first="Jon B." last="Doan">Jon B. Doan</name><name sortKey="Doan, Jon B" sort="Doan, Jon B" uniqKey="Doan J" first="Jon B." last="Doan">Jon B. Doan</name><name sortKey="Suchowersky, Oksana" sort="Suchowersky, Oksana" uniqKey="Suchowersky O" first="Oksana" last="Suchowersky">Oksana Suchowersky</name><name sortKey="Suchowersky, Oksana" sort="Suchowersky, Oksana" uniqKey="Suchowersky O" first="Oksana" last="Suchowersky">Oksana Suchowersky</name><name sortKey="Whishaw, Ian Q" sort="Whishaw, Ian Q" uniqKey="Whishaw I" first="Ian Q." last="Whishaw">Ian Q. Whishaw</name><name sortKey="Whishaw, Ian Q" sort="Whishaw, Ian Q" uniqKey="Whishaw I" first="Ian Q." last="Whishaw">Ian Q. Whishaw</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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